![]() And if enough of us use it, it has the power to make the world a more reasonable place.These engaging, TEKS/TAKS aligned activities create opportunity for K-12 students to explore astronomy, physics and chemistry in the classroom.Įverything has a shadow! Shadows illustrate how three-dimensional objects can be viewed in two dimensions. But it can help us increase the number of positive choices we make.Ĭritical thinking can give us the tools to sift through a sea of information and find what we’re looking for. This five-step process is just one tool, and it certainly won’t eradicate difficult decisions from your life. This will allow you to explore alternatives, evaluate your own choices, and ultimately help you make more informed decisions. Even if you disagree with everything that candidate says, exploring the full spectrum of viewpoints might explain why some policies that don’t seem valid to you, appeal to others. But what about the long-term environmental effects? If gasoline use is less restricted by cost, this could also cause a huge surge in air pollution, an unintended consequence that’s important to think about.Īsk yourself why so many people are drawn to the politics of the opposing political candidate. Imagine it’s election time, and you’ve selected a political candidate based on their promise to make it cheaper for drivers to fill up on gas. When facing a decision, ask yourself, “What concepts are at work?”, “What assumptions exist?”, “Is my interpretation of the information logically sound?”įor example, in an email that promises you millions, you should consider, “What is shaping my approach to this situation?”, “Do I assume the sender is telling the truth?”, “Based on the evidence, is it logical to assume I’ll win any money?” Something you do by asking critical questions. Information gathering helps you weigh different options, moving you closer to a decision that meets your goal. If you’re trying to decide on a diet to improve your nutrition you may ask an expert for their advice or seek other people’s testimonies. There’s lots of it out there, so having a clear idea of your question will help you determine what’s relevant. For example, if you’re deciding whether to try out the newest diet craze, your reasons for doing so may be obscured by other factors, like claims that you’ll see results in just two weeks.īut if you approach the situation with a clear view of what you’re actually trying to accomplish by dieting, whether that’s weight loss, better nutrition or having more energy, that’ll equip you to sift through this information critically, find what you’re looking for and decide whether the new fad really suits your needs. This isn’t always as straightforward as it sounds. In other words, know what you’re looking for. There are many different ways of approaching critical thinking but here’s one five step process that may help you solve any number of problems. Using the tools at their disposal, they’ll eliminate everything but the most useful and reliable information. ![]() Rather than choosing an answer because it feels right, a person who uses critical thinking subjects all available options to scrutiny and skepticism. If the critical part sounds negative, that’s because in a way it is. This is a way of approaching a question that allows us to carefully deconstruct a situation to reveal its hidden issues, such as bias and manipulation, and make the best decision. But there are many ways to improve our chances, and one particularly effective technique is critical thinking. We’re bombarded with so many decisions that it’s impossible to make a perfect choice every time. For example, which politician should I vote for? Should I try the latest diet craze? Some are small and unimportant, but others have a larger impact on our lives. Every day, a sea of decisions stretches before us.
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The second part is more focused about Black Crypt. Stability: How well the player keeps stance after being hitĪttack Type: Defines what kind of swing set the weapon has. The first part is about dungeon crawler game mechanics in general. Weight: How much the item weights when equipped. When an items durability is low, a message will come up saying "Weapon At Risk!" at this point the weapon does not perform at it's best. This resulting bonus damage is added to the base physical damage of the weapon and is shown in the equipment screen in blue numbers as a "+ X".ĭurability: The weapon's HP, when the durability hits 0, the effectiveness of its attacks become weakened to the point of almost uselessness. Check out the first 30 minutes of gameplay for Dungeons & Dragons: Dark Alliance, the new single-player or co-op action game set in the Dungeons and Dragons. The higher the scaling letter, the higher the percent multiplier applied to the. The higher the player's stat, the higher the is (found on the player status screen). Scaling quality is from highest to lowest as follows: S/A/B/C/D/E. Parameter Bonus: Strength, Dexterity,Magic, Fire, Lightning and Dark bonuses - The scaling multiplier applied to the. ![]() It bears resemblance to the Dragonslayer, a giant two-handed sword wielded by Guts, from Berserk (anime/manga).Wielded by Grave Warden Agdayne when he's summoned or aggroed.Two-handed strong attack can knock down enemies, like the Murakumo.It receives S scaling on Dark if infused with Dark.By default it deals Dark damage, it can also be infused with Darknight Stone and buffed with Dark Weapon, best for hexers with high Strength, Intelligence and Faith.Reinforced with Petrified Dragon Bone to +5.Place these to create the twisting passages, creepy. Can only be acquired in NG+ and beyond or by using a Bonfire Ascetic in the Black Gulch in the Hidden Chamber bonfire. Build and explore a new Crypt every game by drawing cards from the dungeon deck to reveal floor tiles.Weaponsmith Ornifex, traded for Old Dead One's soul and 10,000 souls.The sword has never seen the light of day, and is steeped in dark. Ultra greatsword symbolizing guardianship over the Undead Crypt. Dark Heaven Legends Reaper 02990 Crypt of the Vampiress. ![]() *When infused: 333 physical,117 dark and 88 elemental damage.When infused with dark:266 physical and 218 dark dmgĬrypt Blacksword is a weapon in Dark Souls 2. Great for fantasy dungeon skirmish tabletop wargaming, Dungeons & Dragons, Pathfinder, OD&D. ![]() Embed Multi-media: The best thing about Flip PDF Professional is that it lets you embed any media into your flipbook such as audio files, animated text, videos, slideshows, hyperlinks, printable coupons, image galleries, etc.It comes with over 20+ built-in themes and lets you download more free themes from Flip PDF Pro’s server. Customization: You can customize elements like title, background, toolbar icon appearance, logo, shadows, margins, page numbers, links, fonts, flip orientation and more.You can insert multimedia such as image albums, audio, videos, flash and much more into your flipbook.įlipBuilder offers series of different software for you to publish eBooks, deploy newspapers, online magazines, business brochures, annual reports, corporate reports, interactive books, newsletters, event leaflets, product catalogs and more. Flip PDF Professional by FlipBuilder is a desktop application that allows you to fully animate elements of your flipbook. Either build publications from scratch or you can import PDF files and images via a built-in word processor. You can even make Native Flipbook App for Android in this version.įlipBuilder is an innovative digital publishing platform that converts static PDF files into professional-looking online flipbooks. It comes with unlimited storage, unlimited uploads, unlimited pages per book, unlimited bookcases and more. ![]()
![]() ![]() Lawrence, Kansas, USA) would like to thank Ligand Pharmaceuticals Incorporated for funding. Krise*(University of Kansas, Lawrence, Kansas, USA) and J.D. The authors: Randall Logan, Sirantha Perera, and Jeffrey P. International Journal of Pharmaceutics 2011,418,207-216.Īcknowledgements This work was performed in collaboration with the Department of Pharmaceutical Chemistry at The University of Kansas. The assay is amenable to a high throughput screening format to potentially allow for the identification of putative Captisol binding partners from large arrays of unknowns (i.e., fractionated tissue extracts).ġ.Preliminary screens with this assay reveal that sphingosine is a potentially strong binder of Captisol, relative to other molecules screened.The Nile red-based competitive binding assay appears to reliably predict Captisol binding affinity.The concentration of each lipid was 10 μM. The binding affinity with other membrane phospholipids appeared to be significantly less in magnitude suggesting some specificity for sphingosine. Initial screening of endogenous molecules revealed that Captisol appears to bind the sphingoid base sphingosine with high affinity, comparable to progesterone. Screening for endogenous Captisol binders The good correlation between these two assays (R 2 = 0.8) suggests that the Nile red assay can be utilized to predict Captisol binding affinities. The plot reports the % decrease in system FL for each of the 10 molecules using the Nile red competitive binding assay (Y-axis) against the previously reported Captisol binding constant from the literature (X-axis). Using a series of 10 molecules with previously reported 1 low, medium and high Captisol association constants the performance of the Nile red assay was evaluated. The addition of known Captisol binders can competitively displace Nile red and cause a reduction in the system fluorescence in a concentration-dependent manner. Nile red concentration was held constant at 250 nM. The fluorescence of Nile red increases as the concentration of Captisol increases. All measurements are taken in pure H 2O after 24 hour incubation period. The percent decrease in system fluorescence that results from Nile red competitive displacement is mathematically derived according to the equation shown. Two readings are taken to record the total system fluorescence before the unknown analyte is directly exposed to Captisol (total RFU BM) and two more are taken after the all components of the system have been mixed (total RFU AM). Each experimental assessment of binding requires a total of 4 fluorescence readings. Nile red exhibts relatively strong fluorescence when complexed with Captisol and this fluorescence is substantially reduced when another molecule displaces it. In order to assess the binding of Captisol with endogenous analytes, a competitive displacement-type assay employing environmentally sensitive fluorophore Nile red was designed. Ultimately, this assay will be used to screen fractionated biological tissue samples in an effort to identify endogenous binding partners, which may provide information that will help reveal the potential biological effects of cyclodextrins. solubility, pKa, NMR chemical shift, etc.)The purpose of this work was to develop and evaluate an alternative method that could be used to assess the strength Captisol ® interaction with putative binding substrates. Such approaches typically involve titrating cyclodextrin and measuring the effect of binding on drug properties (i.e. Traditional approaches for assessing the binding affinity of drugs with Captisol ® are relatively low-throughput consume relatively large amounts of drug and cyclodextrin. Lawrence, Kansas, USAĬaptisol ® is a sulfonated b-cyclodextrin that forms inclusion complexes with drugs and is utilized as a drug-solubilizing excipient in a variety commercial drug formulations. Krise 1,*ġDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, USAĢLigand Pharmaceuticals Inc. By: Randall Logan 1, Sirantha Perera 1, J.D. ![]() But also I think it's something that is really real and something that a lot of people are facing." Watch the video above to hear her story. ![]() Smooth and refreshing, Hazy-O drinks like a 5 ABV sipper, even thought its a 7.1 ABV powerhouse As the first-ever nationally distributed oat milk-centric IPA, Hazy-O took almost a year of R&D to perfect. lifestyle - my journey in terms of mental health has been one of the hardest struggles I've ever had to share. This foundation of four oat formats creates a target, allowing the beer’s bright and juicy hops to hit the flavorful bullseye. 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Ggrepel::geom_text_repel(label=rownames(mtcars)) + To allow use to customize the regression formula (instead of fixed as y and x as literal variable names), and added the p-value into the printout as well (as T commented), here is the mod: lm_eqn |t|)'], digits=1) # a single fit with grouped data as asked by = dfg, aes(x = x, y = y)) +Ĭreated on by the reprex package (v2.0.1) Ggplot(data = dfg, aes(x = x, y = y, linetype = group, grp.label = group)) + Ggplot(data = dfg, aes(x = x, y = y, colour = group)) + Labs(x = expression(italic(z)), y = expression(italic(h))) + # variable substitution as asked by same labels in equation and axes # adding a hat as asked by and = df, aes(x = x, y = y)) + Stat_poly_eq(formula = y ~ poly(x, 2, raw = TRUE), Stat_poly_line(formula = y ~ poly(x, 2, raw = TRUE)) + Stat_poly_eq(formula = y ~ x + 0, aes(label = after_stat(eq.label))) + Stat_poly_eq(aes(label = after_stat(eq.label))) + # adding separate labels with equation and R2 # assembling a single label with equation and R2 # using default formula, label and methods I have omitted in all code examples the additional arguments to stat_poly_line() as they are irrelevant to the question of adding labels. 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Sn(s) + 2HCl(aq) → SnCl 2(aq) + H 2(g) reacts slowly Zn(s) + 2HCl(aq) → ZnCl 2(aq) + H 2(g) reacts moderatelyįe(s) + 2HCl(aq) → FeCl 2(aq) + H 2(g) reacts slowly Mg(s) + 2HCl(aq) → MgCl 2(aq) + H 2(g) reacts rapidlyĢAl(s) + 6HCl(aq) → 2AlCl 3(aq) + 3H 2(g) reacts rapidly MetalĢK(s) + 2HCl(aq) → 2KCl(aq) + H 2(g) reacts explosivelyĢNa(s) + 2HCl(aq) → 2NaCl(aq) + H 2(g) reacts explosivelyĬa(s) + 2HCl(aq) → CaCl 2(aq) + H 2(g) reacts violently The reactions of the metals with the dilute acids will also indicate how reactive the metals are and this is used to place them in the Reactivity Series.Ī more reactive metal will react more violently with the dilute acid.Ĭheck out the table below on the observations and chemical equation for the reaction of metals with dilute acid. Metal + Dilute Acid → Salt Solution + Hydrogen Gas Most metals react with dilute acids to form a salt solution and hydrogen gas. Sn(s) + H 2O(g) → SnO(s) + H 2(g) reacts readilyī) Reaction of Metals with Dilute Hydrochloric Acid ![]() Zn(s) + H 2O(g) → ZnO(s) + H 2(g) reacts readilyģFe(s) + 4H 2O(g) → Fe 3O 4(s) + 4H 2(g) reacts slowly Mg(s) + H 2O(g) → MgO(s) + H 2(g) violent reactionĢAl(s) + 3H 2O(g) → Al 2O 3(s) + 3H 2(g) reacts readily Mg(s) + 2H 2O(l) → Mg(OH) 2(aq) + H 2(g) very slow reaction MetalĢK(s) + 2H 2O(l) → 2KOH(aq) + H 2(g) violent reactionĢNa(s) + 2H 2O(l) → 2NaOH(aq) + H 2(g) violent reactionĬa(s) + 2H 2O(l) → Ca(OH) 2(aq) + H 2(g) reacts readily Note that a more reactive metal reacts violently with steam.Ĭheck out the table below on the observations and chemical equation for the reaction of metals with cold water and/or steam. Metal + Steam → Metal Oxide + Hydrogen Gas Such metals will react with steam to form metal oxide and hydrogen gas. Some metals such as zinc and iron, do not react with cold water but they do react with steam. Note that a more reactive metal will react more violently with cold water. Metal + Water → Metal Hydroxide + Hydrogen Gas This reaction can be easily represented by the following word equation: The more reactive metals tend to react with cold water to form metal hydroxide (alkaline solution) and hydrogen gas. Reaction of metals with dilute acids such as hydrochloric acidĭetermining the Order of Reactivity of Metals A) Reaction of Metals with Cold Water or Steam.Reaction of metals with cold water or steam.The order of reactivity of metals are determined by the scientists based on the: So how is the order of reactivity of metals being determined? In the Reactivity Series, metals are arranged from the most reactive to the least reactive. In case you have missed that blog post which comes with a learning Chemistry Youtube Video, do check it out. In the previous blog post, we have discussed on the importance of the Reactivity Series of Metals as well as the mnemonic (super memory technique) to remember the sequence of metals in terms of their relative reactivities. Source: Science Photo (Reaction of Metals with Hydrochloric Acid) ![]() Our areas of consideration per objective to be met: Objective Create demand for solar lampsĪchieve affordability and easier access for d.light productsĪreas for Consideration Need to stimulate trial Consumers not actively looking, though there is huge latent demand Consider partnering with institutions who can educate people how to use product Trust is hard to earn given plethora of fake and poor-quality brands Consider partnering with institutions that consumers already trust, and halo from them, as long as the institutions are aligned with d.light’s mission. The ideal is to profit by helping a particular segment solve their social problems. ![]() ![]() As stated in the case’s synopsis, it is in the best interest of the founders to reconcile both money and mission – they must choose the best marketing channel strategy that allows them to profit while at the same time helping a particular segment. The team has limited resources, therefore has limitations on adapting all distribution channel. Areas of Considerations and Major Assumptions Our team assumes the following: 1. In addition, the marketing channel strategy should be aligned to the desire of the founders to manage d.light as a for-profit social enterprise – reconciling money and mission. light products to different marketing channel specifically for retailers and consumers. 3.) Understand ways on how to set price aligned of providing product access to different market segments 4.) Define ways on how to distribute d. 2.) Determine ways on how to build trust with unknown brand to customer. In response, d.light would like to set the following objectives aligned with their marketing – channel strategy: 1.) Identify ways on how tocreate demand for solar lamps. Objectives Goldman and Tozun decided that the economic and ethnographic evidence pointed to a clear latent demand among Indian consumers for reliable, affordable light and power solutions. Choosing to distribute products to retailers and/or consumers. Achieve affordability and easier access for d.light products 4. Statement of the Problem/s The main problem the d.light founders must address is how to design the best marketing channel strategy? Should the company employ a single or a multi-channel strategy? Below are key consideration areas that should be tackled: 1. (Household Income and debt) Household and businesses that were electrified faced frequent blackouts with many facing energy losses of fifteen or more hours per day (Electrification in India) Literacy and media exposure in Rural is low compared to Urban specifically for women (Literacy and media exposure). Consequently, it follows that majority of rural households were found to have outstanding debts including local financing organization, multiple parties, friends and family and local shopkeepers. Rural Geographies) The majority of Indians in rural areas earned their livings through agricultural work therefore having below income level. Since 70% of Indian Citizens still lived in Rural Areas, majority still use kerosene which can be prone to accidents. As such, Tozun and Goldman founded d.light with the vision of being a for-profit social enterprise, with success measured both through profits and through lives positively affected. Paul Polak’s concept of using modern product design and development techniques into an emerging market context. According to Ned Tozun, “Our mission is to eradicate the use of kerosene” – rooted from a Stanford Graduate School of Business course Design for Extreme Affordability. Sam Goldman founded d.light Design in New Delhi, India in December 2009. 12 Hog market.Error! Bookmark not defined. 4 Areas of Considerations and Major Assumptions. Tiu, Anthony Albert Marketing Strategy on ProductĬontents Synopsis. Submitted in Partial Fulfillment of the requirements in Marketing Management 1st Term, A.Y. Del Rosario College of Business Master of Business Administration ![]() Tucked away at the back of the controller is the Z button, which by default, your left index finger will rest on top of. However, many games do support left-handed control options, which is where that three-pronged design shines, even if it's a bit underused. 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The colored buttons juxtapose nicely against the slate grey controller, and its form factor, while certainly strange, has a unique charm to it. The N64 controller for Switch, unsurprisingly, bears a striking resemblance to the pad of old. |
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